Escherichia coli ranks very high among bacteria isolated from clinical specimens. From 1987 to 1992, E. coli isolated from various clinical specimens were tested for resistance to antimicrobial drugs. Most of the strains tested were susceptible
to
quinolone carboxylic acid compounds(QA), moxalactam (MX), amikacin (AK), and rifampin(Rf), but other drugs tested showed very low antimicrobial activities against the majority of strains. Especially, resistance frequency of E. coli against
cephalothin,
cefamandole, and gentamicin have been increased gradually during last 6 years 90% MIC of drugs tested were very high except A, Mx, Ak and Rf and over 50% of organisms multiflying resistance to 6 or more drugs were noted. Of importance bas
been
the steadily increasing resistance of E. coli to many antibiotics from 1987 to present. However, reversal of these trends of antimicrobial resistance may result from more specifically directed choices of drugs for infectious diseases, reduction
in
the
excessive uses of antibiotics, the use of more rational dosage regimens, and discontinuance of general and routine antibiotic prophyactic regimens in hospitals.
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